The film portrays the somewhat fictional Grizzly Adams as a frontier woodsman who fled into the mountains in the year 1853, after he was accused of a murder he didn't commit. While struggling to survive, Adams saves an orphaned grizzly bear cub he adopts and names Ben. The bear, while growing to its huge adult size, becomes Adams' closest companion. Consistently kind and gentle, Adams discovers and demonstrates an uncanny ability to gain the trust of most of the indigenous wildlife of the region, and he helps, sometimes rescues, takes in and tames many species. Originally a hunter, with his learned affection for wildlife Adams resolves never to harm another animal whenever possible. Adams also gains two human friends, an old mountain man trader named "Mad Jack" who is often featured with his mule ("Number Seven"), and a Native American by the name of "Nakoma". Adams, Mad Jack, and Nakoma help myriad mountain visitors while protecting wildlife at the same time.