What's the difference between genetic (DNA and mRNA) vaccines and viral vector vaccines? This video does a good job explaining how these different type of new and experimental vaccine technologies work. Don't worry that none of them have ever been tried on humans before now, or ever made it past stage 3 animal clinical trials, just get the shot, because being part of a science experiment is fun!!! Original video found here: https://youtu.be/KMc3vL_MIeo 'Leading COVID-19 vaccine candidates rely on new technologies that have fast-tracked development and testing. Vaccines from Pfizer and Moderna have completed early phase 3 clinical trials and are reportedly under review at the US FDA for emergency use authorization (EUA) although safety surveillance continues. This video explains the principles underlying the leading DNA, messenger RNA (mRNA), and viral vector vaccine candidates, and how they might induce immunity to SARS-CoV-2 infection. 0:00 Introduction 1:21 Traditional vaccines 2:00 COVID-19 vaccine types in development 2:18 Making vaccines from a genetic sequence 2:45 Target antigen: the S protein 3:32 Genetic vaccines (DNA and mRNA) 4:18 Moderna/NIH and Pfizer/BioNTech vaccines 4:52 Viral vector vaccines 5:42 Adenovirus vectors (University of Oxford/AstraZeneca and Johnson & Johnson/Janssen Pharmaceuticals) 6:32 rVSV vector vaccine (Merck/IAVI) 7:15 Previous experience with next generation vaccines 7:50 Importance of Phase 3 Trials For full livestreams featured in this video: Anthony S. Fauci, MD, January 27, 2020: https://youtu.be/3qlagdc_luM Paul A. Offit, MD, June 1, 2020: https://youtu.be/2DUiBlj5rsQ Robert Redfield, MD, July 14, 2020: https://youtu.be/jzHIhSZ_fiA --------------------------------------------------------------------------------- • Coronavirus Resource page from the JAMA Network: https://ja.ma/covidyt • To watch JAMA Live Q&A's Visit: https://ja.ma/covidqaytpl